{"title":"Mental Health \u0026 Stress Support","description":null,"products":[{"product_id":"calm-mind","title":"Calm Mind","description":"\u003cp\u003eBenefits \u0026amp; Features\u003cbr\u003e\n• Supports emotional well-being‡\u003cbr\u003e\n• Supports a positive mood and emotional outlook‡\u003cbr\u003e\n• Promotes a calm state of mind‡\u003cbr\u003e\n• Supports sleep with continued use‡\u003cbr\u003e\n• Clinically studied saffron (affron®)\u003cbr\u003e\n• Clinically studied curcumin (Theracurmin®) with 27x enhanced bioavailability\u003cbr\u003e\nIndications\u003cbr\u003e\n• Patients seeking support for mood and emotional well-being‡\u003cbr\u003e\n• Patients experiencing occasional stress and\/or sleeplessness‡\u003c\/p\u003e\n\n\u003cp\u003eSuggested Use\u003cbr\u003e\nAs a dietary supplement, take 1 capsule, 2 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research\u003cbr\u003e\nVerifiable Science\u003cbr\u003e\nCalm Mind combines two clinically studied botanical extracts, saffron (affron®) and curcumin (Theracurmin®), to support a positive mood, a calm state of mind and emotional well being. In a double-blind trial involving 128 adults self-reporting low mood, saffron (affron®, 28 mg\/day) resulted in a significant decrease in negative mood and symptoms related to stress after 4 weeks compared to placebo.1\u003c\/p\u003e \n\n\u003cp\u003eOther studies indicate that saffron also supports sleep with continued use.2-4\u003c\/p\u003e \n\n\u003cp\u003eThe regulation of mood and emotional state is influenced by the immune system, and emerging research points to an impactful role of immune mediators known as cytokines.5\u003c\/p\u003e \n\n\u003cp\u003eLower plasma levels of certain cytokines, such as IL-6 and TNF-α, are associated with positive mood and emotional well-being.5, 6\u003c\/p\u003e\n\n\u003cp\u003eIn preclinical models, curcumin moderates the production of the cytokines IL-1β, IL-6, and TNF-α5, 6 and moderates pro-inflammatory cytokine pathways in the brain.7, 8\u003c\/p\u003e \n\n\u003cp\u003eHowever, the low oral bioavailability of curcumin may limit its ability to support brain function. Theracurmin® is 27 times more bioavailable than standard curcumin.9\u003c\/p\u003e \n\n\u003cp\u003eIn a study of 40 adults (51–84 years of age) Theracurmin® containing 90 mg curcumin twice daily for 18 months significantly improved short-term, verbal and visual memory and attention.10‡\u003c\/p\u003e\n\n\u003cp\u003eReferences\u003cbr\u003e\nKell G, et al. Complement Ther Med. 2017 Aug;33:58-64.\u003cbr\u003e\nNishide A, et al. Jpn Pharmacol Ther. 2018;46:8.\u003cbr\u003e\nLopresti AL, et al. Sleep Med. 2021 Oct;86:7-18.\u003cbr\u003e\nLopresti AL et al. J Clin Sleep Med. 2020 Jun 15;16(6):937-947.\u003cbr\u003e\nHassamal S. Front Psychiatry. 2023 May 11;14:1130989.\u003cbr\u003e\nFan N, et al. Hum Psychopharmacol. 2017 Jul;32(4).\u003cbr\u003e\nFan C, et al. Neuroscience. 2018 Nov 10;392:92-106.\u003cbr\u003e\nWang Z, et al. Behav Brain Res. 2014 Nov 1;274:282-90.\u003cbr\u003e\nSasaki H, et al. Biol Pharm Bull. 2011;34(5):660-5.\u003cbr\u003e\nSmall GW, et. al. Am J Geriatr Psychiatry. 2018 Mar;26(3):266-277\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":53129799401696,"sku":null,"price":66.5,"currency_code":"USD","in_stock":true}]},{"product_id":"daily-calm","title":"Daily Calm","description":"\u003cp\u003e• Supports relaxation with continued use‡\u003c\/p\u003e\n\n\u003cp\u003e• Supports a positive mood‡\u003c\/p\u003e\n\n\u003cp\u003e• Supports a relaxed and alert mental state‡\u003c\/p\u003e\n\n\u003cp\u003e• Supports sleep with continued use‡\u003c\/p\u003e\n\n\u003cp\u003e• Clinically studied L-theanine (Suntheanine®)\u003c\/p\u003e\n\n\u003cp\u003e• Clinically studied ashwagandha (KSM-66®)\u003c\/p\u003e\n\n\u003cp\u003e• Clinically studied saffron (affron®)\u003cbr\u003e\n \u003cbr\u003e\nIndications\u003cbr\u003e\n• Ages 18 and up\u003c\/p\u003e\n\n\u003cp\u003e• Occasional anxiety‡\u003c\/p\u003e\n\n\u003cp\u003e• Occasional stress‡\u003c\/p\u003e\n\n\u003cp\u003eSuggested Use\u003cbr\u003e\nAs a dietary supplement, take 1 capsule, 2 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research\u003cbr\u003e\nVerifiable Science\u003cbr\u003e\nDaily Calm combines L-theanine, saffron, GABA, and ashwagandha to relieve occasional stress and anxiety while supporting a positive, relaxed mood and emotional well-being. Suntheanine®, a trademarked L-theanine, supports a relaxed and alert mental state. A four-week randomized clinical trial using L-theanine found support for stress-related symptoms.1\u003c\/p\u003e\n\n\u003cp\u003eClinical research shows that saffron, a widely studied spice derived from the flower of Crocus sativus, supports emotional well-being and positive mood.2-4\u003c\/p\u003e \n\n\u003cp\u003eClinical studies also show that saffron supports sleep with continued use.5,6\u003c\/p\u003e \n\n\u003cp\u003eAshwagandha, an adaptogenic herb, helps the body adapt to stress by restoring balance. Studies show that ashwagandha supports a calm, relaxed mood, helping to relieve occasional anxiety and stress.7-9\u003c\/p\u003e \n\n\u003cp\u003eTogether, these ingredients support multiple aspects of emotional wellness, helping to relieve occasional stress and anxiety while supporting a positive emotional outlook and sleep quality with continued use.‡\u003c\/p\u003e\n\n \u003cbr\u003e\n\u003cp\u003eReferences\u003cbr\u003e\nHidese S, Ogawa S, Ota M, et al. Nutrients. 2019 Oct 3;11(10):2362.\u003c\/p\u003e\n\n\u003cp\u003eTóth B, Hegyi P, Lantos T, et al. Planta Med. 2019 Jan;85(1):24-31. doi: 10.1055\/a-0660-9565.\u003c\/p\u003e\n\n\u003cp\u003eKashani L, Eslatmanesh S, Saedi N, et al. Pharmacopsychiatry. 2017 Mar;50(2):64-68. doi: 10.1055\/s-0042-115306.\u003c\/p\u003e\n\n\u003cp\u003eKell G, Rao A, Beccaria G, et al. Complement Ther Med. 2017 Aug;33:58-64. doi: 10.1016\/j.ctim.2017.06.001.\u003c\/p\u003e\n\n\u003cp\u003ePachikian BD, Copine S, Suchareau M, Deldicque L. Nutrients. 2021 Apr 27;13(5):1473. doi: 10.3390\/nu13051473.\u003c\/p\u003e\n\n\u003cp\u003eLopresti AL, Smith SJ, Metse AP, Drummond PD. J Clin Sleep Med. 2020 Jun 15;16(6):937-947. doi: 10.5664\/jcsm.8376.\u003c\/p\u003e\n\n\u003cp\u003eLangade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Cureus. 2019 Sep 28;11(9):e5797. doi: 10.7759\/cureus.5797.\u003c\/p\u003e\n\n\u003cp\u003eSalve J, Pate S, Debnath K, Langade D. Cureus. 2019 Dec 25;11(12):e6466.\u003c\/p\u003e\n\n\u003cp\u003eKelgane SB, Salve J, Sampara P, Debnath K. Cureus 2020; 12(2): e7083.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":53129806643424,"sku":null,"price":47.5,"currency_code":"USD","in_stock":true}]},{"product_id":"rapid-calm","title":"Rapid Calm","description":"\u003cp\u003eRapid Calm delivers rapid-acting support for occasional anxiety in less than one hour. Zembrin®, a patented extract of Sceletium tortuosum, has been clinically studied and shown to help moderate general feelings of stress and occasional anxiety. In a clinical trial, a single dose of 25 mg Zembrin® reduced perceived levels of occasional anxiety and its physical symptoms, such as elevated heart rate, in healthy volunteers, within 1 hour.1 In another randomized clinical trial, a single 25 mg dose of Zembrin® moderated fear responsivity and activation of the brain's amygdala, assessed using pharmaco-fMRI.2 The amygdala is a part of the brain that reacts to threats and communicates with the rest of the related areas of the brain to regulate feelings of fear and nervousness in threatening situations. In vitro evidence indicates that Zembrin® might work by inhibiting serotonin reuptake, prolonging the effects of serotonin.3 Serotonin is a neurotransmitter involved in relaxation and mood. L-theanine complements Zembrin® by supporting a relaxed and alert mental state.4 Vitamin B6 is a cofactor in the biosynthesis of serotonin.5 This formula is ideal for as-needed relief from occasional everyday stressors.‡\u003c\/p\u003e\n\n \u003cbr\u003e\n\u003cp\u003eReferences\u003cbr\u003e\nReay J, Wetherell MA, Morton E. Hum Psychopharmacol. 2020 Nov;35(6):1-7. doi: 10.1002\/hup.2753. Epub 2020 Aug 6. PMID: 32761980.\u003cbr\u003e\nTerburg D, Syal S, Rosenberger LA, et al. Neuropsychopharmacology. 2013 Dec;38(13):2708-16. doi: 10.1038\/npp.2013.183.\u003cbr\u003e\nHarvey AL, Young LC, Viljoen AM, Gericke NP. J Ethnopharmacol. 2011 Oct 11;137(3):1124-9. doi: 10.1016\/j.jep.2011.07.035.\u003cbr\u003e\nHidese S, Ogawa S, Ota M, et al. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390\/nu11102362.\u003cbr\u003e\nBlau N, Pearson TS, Kurian MA, et al. 2023 Oct 12. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":53129830826208,"sku":null,"price":47.5,"currency_code":"USD","in_stock":true}]},{"product_id":"rapid-mental-energy","title":"Rapid Mental Energy","description":"\u003cp\u003e• Sharpens working memory‡\u003c\/p\u003e\n\n\u003cp\u003e• Supports alertness‡\u003c\/p\u003e\n\n\u003cp\u003e• Supports cognitive performance‡\u003c\/p\u003e\n\n\u003cp\u003e• Two clinically backed ingredients\u003c\/p\u003e\n\n\u003cp\u003e• Not known to interfere with sleep\u003c\/p\u003e\n\n\u003cp\u003e• Can be safely used with caffeine\u003cbr\u003e\n \u003cbr\u003e\nIndications\u003cbr\u003e\n• Ages 18 and up\u003c\/p\u003e\n\n\u003cp\u003e• As-needed support for alertness and working memory‡\u003c\/p\u003e\n\n\u003cp\u003eSuggested Use\u003cbr\u003e\nAs a dietary supplement, take 1 capsule as needed, with or between meals, or as directed by a health professional.\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research\u003cbr\u003e\nVerifiable Science\u003cbr\u003e\nRapid Mental Energy combines clinically studied extracts, Alpinia galanga (enXtra) and American ginseng (Cereboost®), to support alertness and sharpen working memory.1-5\u003c\/p\u003e \n\n\u003cp\u003eIn a randomized, double-blind, placebo-controlled crossover study, enXtra significantly increased alertness scores from baseline values at 1 hour, 3 hours and 5 hours after a single 300 mg dose.1\u003c\/p\u003e \n\n\u003cp\u003eAlertness scores were significantly greater in the enXtra group compared to placebo (p=0.04) at 3 hours post-dose. While enXtra supports alertness and attention network function (the ability to direct mental resources to a specific task), Cereboost® provides fast-acting support for acute visuospatial and verbal short-term (working) memory.1-5 \u003cbr\u003e\nin a study of 52 healthy middle-aged adults, Cereboost® (200 mg) improved working memory 3 hours after a single dose.2\u003c\/p\u003e \n\n\u003cp\u003eIn a randomized controlled clinical trial of 61 healthy young adults, daily use of Cereboost® (200 mg) improved working memory and attention.3 In a randomized, double-blind crossover trial of 32 healthy volunteers, a single dose of Cereboost® (200 mg) improved working memory (immediate word recall and visuo-spatial information retrieval) at 1 hour post-dose and was sustained over a 6 hour testing period.4\u003c\/p\u003e \n\n\u003cp\u003eThe ginsenosides in Cereboost® support cholinergic neurotransmission in the hippocampus and prefrontal cortex, key brain regions involved in learning and memory.5 ‡\u003c\/p\u003e\n\n\u003cp\u003eReferences\u003cbr\u003e\nSrivastava S, Mennemeier M, Pimple S. J Am Coll Nutr. 2017 Nov-Dec;36(8):631-639. doi: 10.1080\/07315724.2017.1342576.\u003c\/p\u003e\n\n\u003cp\u003eBell L, Whyte A, Duysburgh C, et al. Eur J Nutr. 2022 Feb;61(1):413-428.\u003c\/p\u003e\n\n\u003cp\u003eOssoukhova A, Owen L, Savage K, et al. Human Psychopharmacol. 2015;30(2):108–122.\u003c\/p\u003e\n\n\u003cp\u003eScholey A, Ossoukhova A, Owen L, et al. Psychopharmacology. 2010;212(3):345–356.\u003c\/p\u003e\n\n\u003cp\u003eShin K, Guo H, Cha Y, et al. Regul Toxicol Pharmacol. 2016 Jul;78:53-8.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":53129830858976,"sku":null,"price":33.25,"currency_code":"USD","in_stock":true}]}],"url":"https:\/\/www.saveusrx.com\/collections\/mental-health-stress-support.oembed","provider":"Saveusrx","version":"1.0","type":"link"}