{"product_id":"calm-mind","title":"Calm Mind","description":"\u003cp\u003eBenefits \u0026amp; Features\u003cbr\u003e\n• Supports emotional well-being‡\u003cbr\u003e\n• Supports a positive mood and emotional outlook‡\u003cbr\u003e\n• Promotes a calm state of mind‡\u003cbr\u003e\n• Supports sleep with continued use‡\u003cbr\u003e\n• Clinically studied saffron (affron®)\u003cbr\u003e\n• Clinically studied curcumin (Theracurmin®) with 27x enhanced bioavailability\u003cbr\u003e\nIndications\u003cbr\u003e\n• Patients seeking support for mood and emotional well-being‡\u003cbr\u003e\n• Patients experiencing occasional stress and\/or sleeplessness‡\u003c\/p\u003e\n\n\u003cp\u003eSuggested Use\u003cbr\u003e\nAs a dietary supplement, take 1 capsule, 2 times daily, between meals, or as directed by a health professional.\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research\u003cbr\u003e\nVerifiable Science\u003cbr\u003e\nCalm Mind combines two clinically studied botanical extracts, saffron (affron®) and curcumin (Theracurmin®), to support a positive mood, a calm state of mind and emotional well being. In a double-blind trial involving 128 adults self-reporting low mood, saffron (affron®, 28 mg\/day) resulted in a significant decrease in negative mood and symptoms related to stress after 4 weeks compared to placebo.1\u003c\/p\u003e \n\n\u003cp\u003eOther studies indicate that saffron also supports sleep with continued use.2-4\u003c\/p\u003e \n\n\u003cp\u003eThe regulation of mood and emotional state is influenced by the immune system, and emerging research points to an impactful role of immune mediators known as cytokines.5\u003c\/p\u003e \n\n\u003cp\u003eLower plasma levels of certain cytokines, such as IL-6 and TNF-α, are associated with positive mood and emotional well-being.5, 6\u003c\/p\u003e\n\n\u003cp\u003eIn preclinical models, curcumin moderates the production of the cytokines IL-1β, IL-6, and TNF-α5, 6 and moderates pro-inflammatory cytokine pathways in the brain.7, 8\u003c\/p\u003e \n\n\u003cp\u003eHowever, the low oral bioavailability of curcumin may limit its ability to support brain function. Theracurmin® is 27 times more bioavailable than standard curcumin.9\u003c\/p\u003e \n\n\u003cp\u003eIn a study of 40 adults (51–84 years of age) Theracurmin® containing 90 mg curcumin twice daily for 18 months significantly improved short-term, verbal and visual memory and attention.10‡\u003c\/p\u003e\n\n\u003cp\u003eReferences\u003cbr\u003e\nKell G, et al. Complement Ther Med. 2017 Aug;33:58-64.\u003cbr\u003e\nNishide A, et al. Jpn Pharmacol Ther. 2018;46:8.\u003cbr\u003e\nLopresti AL, et al. Sleep Med. 2021 Oct;86:7-18.\u003cbr\u003e\nLopresti AL et al. J Clin Sleep Med. 2020 Jun 15;16(6):937-947.\u003cbr\u003e\nHassamal S. Front Psychiatry. 2023 May 11;14:1130989.\u003cbr\u003e\nFan N, et al. Hum Psychopharmacol. 2017 Jul;32(4).\u003cbr\u003e\nFan C, et al. Neuroscience. 2018 Nov 10;392:92-106.\u003cbr\u003e\nWang Z, et al. Behav Brain Res. 2014 Nov 1;274:282-90.\u003cbr\u003e\nSasaki H, et al. Biol Pharm Bull. 2011;34(5):660-5.\u003cbr\u003e\nSmall GW, et. al. Am J Geriatr Psychiatry. 2018 Mar;26(3):266-277\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":53129799401696,"sku":null,"price":66.5,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.saveusrx.com\/products\/calm-mind","provider":"Saveusrx","version":"1.0","type":"link"}