{"product_id":"nr-longevity","title":"NR Longevity","description":"\u003cp\u003e• Age better by targeting the effects of aging from the inside, at the cellular level‡\u003c\/p\u003e\n\n\u003cp\u003e• Decreases the effects of cellular aging‡\u003c\/p\u003e\n\n\u003cp\u003e• Helps to replenish NAD+‡\u003c\/p\u003e\n\n\u003cp\u003e• Enhances mitochondrial function‡\u003c\/p\u003e\n\n\u003cp\u003e• Supports antioxidant defenses‡\u003c\/p\u003e\n\n\u003cp\u003e• Includes Nicotinamide riboside (NR) to promote the synthesis of NAD+, a key driver of cellular energy production‡\u003cbr\u003e\n \u003cbr\u003e\nIndications\u003cbr\u003e\n• Healthy aging support‡\u003c\/p\u003e\n\n\u003cp\u003eSuggested Use\u003cbr\u003e\nAs a dietary supplement, take 2 capsules, 1-2 times daily, with or between meals.\u003c\/p\u003e\n\n\u003cp\u003eScience \u0026amp; Research\u003cbr\u003e\nVerifiable Science\u003cbr\u003e\nNR Longevity is specially designed to target biological processes that decline with age, such as the body’s natural ability to make energy, build new mitochondria and protect cells from oxidative stress.1\u003c\/p\u003e \n\n\u003cp\u003eNicotinamide riboside (NR), resveratrol and sulforaphane promote healthy aging by replenishing NAD+, enhancing mitochondrial function and providing antioxidant support, respectively. Nicotinamide riboside (NR) is a form of vitamin B3 that acts as a precursor of nicotinamide adenine dinucleotide (NAD+), which plays a critical role in cellular energy production.2-4\u003c\/p\u003e \n\n\u003cp\u003eNAD+ activates enzymes in the sirtuin family, considered to be master switches of metabolism and regulators of aging. Notably, NAD+ activates SIRT1, an epigenetic switch that regulates metabolism and supports mitochondrial biogenesis, cellular energy production and cellular longevity.5,6\u003c\/p\u003e \n\n\u003cp\u003eHigher NAD+ levels are associated with healthy mitochondrial function.7,8\u003c\/p\u003e \n\n\u003cp\u003eConversely, cellular NAD+ levels decline with age, and can decrease by up to 50% over the adult lifespan.7-11\u003c\/p\u003e \n\n\u003cp\u003eSupplementing with NR enhances NAD+ levels, supporting the function of NAD+ dependent enzymes that maintain cellular energy production and repair. NR has been clinically shown to increase NAD+ levels in as little as 2 weeks.2\u003c\/p\u003e \n\n\u003cp\u003eResveratrol and sulforaphane promote longevity in model organisms.12-14\u003c\/p\u003e \n\n\u003cp\u003eBoth compounds enhance cellular antioxidant defenses, helping to protect cells against oxidative stress that increases with age and contributes to age-related cellular decline.1,15-18\u003c\/p\u003e \n\n\u003cp\u003eResveratrol activates the AMPK\/SIRT1\/PGC-1alpha axis, a pathway that enhances mitochondrial function and supports normal cellular repair while sulforaphane activates Nrf2, a genomic switch that stimulates expression of genes involved in antioxidant defense, cellular protection and mitochondrial biogenesis.12,13,15-20\u003c\/p\u003e \n\n\u003cp\u003eNrf2 is a transcription factor that supports robust, long-lasting expression of numerous genes responsible for phase II detoxification and protection against oxidative stress. Among these genes are glutathione peroxidase, superoxide dismutase and various phase II enzymes, such as glutathione sulfotransferases. Nrf2 also supports expression of glutathione glutamylcysteinyl ligase, which is responsible for a critical step in the biosynthesis of glutathione, a vital component of cellular antioxidant and detoxification systems.15-18 ‡\u003c\/p\u003e\n\n \u003cbr\u003e\n\u003cp\u003eReferences\u003cbr\u003e\nGhanim H, Sia CL, Abuaysheh S, et al. J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8.\u003c\/p\u003e\n\n\u003cp\u003eConze D, Brenner C, Kruger CL. Sci Rep. 2019 Jul 5;9(1):9772.\u003c\/p\u003e\n\n\u003cp\u003eTrammell SA, Schmidt MS, Weidemann BJ, et al. Nat Commun. 2016 Oct 10;7:12948.\u003c\/p\u003e\n\n\u003cp\u003eCovarrubias AJ, Perrone R, Grozio A, Verdin E. Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141.\u003c\/p\u003e\n\n\u003cp\u003eChen C, Zhou M, Ge Y, Wang X. Mech Ageing Dev. 2020;Apr;187:111215.\u003c\/p\u003e\n\n\u003cp\u003eTang BL. Mol Cells. 2016 Feb;39(2):87-95.\u003c\/p\u003e\n\n\u003cp\u003eJanssens GE, Grevendonk L, Perez RZ, et al. Nat Aging. 2022 Mar;2(3):254-263.\u003c\/p\u003e\n\n\u003cp\u003eChu X, Raju RP. Metabolism. 2022; Jan;126:154923.\u003c\/p\u003e\n\n\u003cp\u003eClement J, Wong M, Poljak A, et al. Rejuvenation Res. 2019 Apr;22(2):121-130.\u003c\/p\u003e\n\n\u003cp\u003eMcReynolds MR, Chellappa K, Baur JA. Exp Gerontol. 2020 Feb 22;134:110888.\u003c\/p\u003e\n\n\u003cp\u003eBratic A, Larsson NG. J Clin Invest. 2013 Mar;123(3):951-7.\u003c\/p\u003e\n\n\u003cp\u003eHowitz KT, Bitterman KJ, Cohen HY, et al. Nature. 2003;425:191–196.\u003c\/p\u003e\n\n\u003cp\u003eWood JG, Rogina B, Lavu S, et al. Nature. 2004;430:686–689.\u003c\/p\u003e\n\n\u003cp\u003eQi Z, Ji H, Le M, et al. Aging (Albany NY). 2021 Jan 20;13(2):1649-1670.\u003c\/p\u003e\n\n\u003cp\u003eBai Y, Wang X, Zhao S, et al. Oxid Med Cell Longev. 2015;2015:407580.\u003c\/p\u003e\n\n\u003cp\u003eCalabrese EJ, Kozumbo WJ. Pharmacol Res. 2021 Jan;163:105283.\u003c\/p\u003e\n\n\u003cp\u003eSun Y, Zhou S, Guo H, et al. Metabolism. 2020 Jan;102:154002.\u003c\/p\u003e\n\n\u003cp\u003eZhao F, Zhang J, Chang N. Eur J Pharmacol. 2018 Apr 5;824:1-10.\u003c\/p\u003e\n\n\u003cp\u003eTimmers S, Konings E, Bilet L, et al. Cell Metab. 2011 Nov 2;14(5):612-22.\u003c\/p\u003e\n\n\u003cp\u003ePrice NL, Gomes AP, Ling AJ, et al. Cell Metab. 2012 May 2;15(5):675-90.\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":53129820045536,"sku":null,"price":61.75,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.saveusrx.com\/products\/nr-longevity","provider":"Saveusrx","version":"1.0","type":"link"}